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The imply AUC(0-∞) was 42% higher in topics with impaired hepatic operate than in wholesome volunteers. The imply half-life of atazanavir in hepatically impaired topics was 12.1 hours in comparison with 6.4 hours in wholesome volunteers. In healthy topics, the renal elimination of unchanged atazanavir was roughly 7% of the administered dose. In addition, it's endorsed that didanosine be administered on an empty stomach; due to this fact, REYATAZ should be given (with meals) 2 h earlier than or can minors buy viagra 1 h after didanosine buffered formulations. When coadministered with tenofovir, it is recommended that REYATAZ 300 mg is given with ritonavir one hundred mg and tenofovir 300 mg (all as a single dailydose with meals). The FDA despatched a discover out this past week concerning drug-drug interactions between Reyataz (atazanavir) and tenofovir (Viread) and likewise Viagra and related drugs. The pharmacokinetics of atazanavir in pediatric patients are beneath investigation. Atazanavir is metabolized and eradicated primarily by the liver.