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Jennifer Van Eyk, Ph.D., a professor on the Johns Hopkins University Faculty of Drugs and its Heart and Vascular Institute. Van Eyk, director of the Johns Hopkins NHLBI Proteomics Group and the Proteomics Middle at Johns Hopkins Bayview Medical Heart. PDE5A is identical enzyme that earlier Johns Hopkins work in mice showed is slowed down by the drug sildenafil (levitra vs viagra), resulting in a reverse of tissue injury from coronary heart enlargement, or hypertrophy, and potentially coronary heart failure. Separate chemical makes an attempt at S-nitrosylation of each pool gradually showed that if cysteine 181 was unavailable to react, then enzymatic activity proceeded at the identical price as in a management group with all cysteines free to react. As cysteine is the only amino acid to which an S-nitrosyl group can attach, Murray's subsequent step was to slim the search from among the 20-plus possible cysteine locations present in PDE5A. Among the 13 circadian period-shortening compounds that the group identified, the researchers targeted on a steroid hormone, dehydroepiandrosterone (DHEA), which is commercially available as an anti-aging complement in USA. Researchers say their next steps are to analyze how PDE5A affects where cyclic GMP is broken down or made, with the goal of determining if the enzyme additionally controls the known cell pooling of the compound.

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