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As the toxin is transported by means of the Golgi and ER, it is additional processed and activated. Vesicles that go to late endosomes (finally lysosomes) from the Golgi or the plasma membrane are clathrin-coated. CHAPTER 10 / RELATIONSHIP BETWEEN CELL BIOLOGY AND BIOCHEMISTRY 177 Vesicles released from the trans face of the Golgi complex journey to endosomes as clathrin-coated vesicles. The hormone Exocytotic vesicles launch proteins into the extracellular space after fusion insulin is synthesized as a prohor- of the vesicular and plasma cell membranes. Clathrin Trans-Golgi Medial-Golgi COPI Cis-Golgi COPI COPII ER-golgi Fusion intermediate of COPII compartment vesicles Rough ER Fig. COP II vesicles (coatomer- coated) kind in the tough ER and move to the Golgi. COP I vesicles generally go from the trans to the cis Golgi to the ER. ADP-ribosylating factor), and online canadian pharmacy COP II vesicles include the monomeric G protein Sar (another member of the Arf family). SNARE) on the target membrane, thus making certain that COP I vesicles.

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